CATH Domain 3tfqE00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P28845

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_HUMAN

Homo sapiens

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	3TFQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1) Wu, S.C., Yoon, D., Chin, J., van Kirk, K., Seethala, R., Golla, R., He, B., Harrity, T., Kunselman, L.K., Morgan, N.N., Ponticiello, R.P., Taylor, J.R., Zebo, R., Harper, T.W., Li, W., Wang, M., Zhang, L., Sleczka, B.G., Nayeem, A., Sheriff, S., Camac, D.M., Morin, P.E., Everlof, J.G., Li, Y.X., Ferraro, C.A., Kieltyka, K., Shou, W., Vath, M.B., Zvyaga, T.A., Gordon, D.A., Robl, J.A. Bioorg.Med.Chem.Lett.