The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rap/Ran-GAP
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Tuberous sclerosis 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
4 M9PD17 (/IDA) Q7K0T0 (/IDA) Q9U9B0 (/IDA) Q9VW83 (/IDA)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
4 M9PD17 (/IPI) Q7K0T0 (/IPI) Q9U9B0 (/IPI) Q9VW83 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q7K0T0 (/IPI) Q9UUG9 (/IPI)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q9UUG9 (/IMP)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 A0A1D8PMB6 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q7K0T0 (/IPI)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
5 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9UUG9 (/IMP) Q9VW83 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 M9PD17 (/IDA) Q7K0T0 (/IDA) Q9U9B0 (/IDA) Q9VW83 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Larval midgut histolysis GO:0035069
The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
4 M9PD17 (/IDA) Q7K0T0 (/IDA) Q9U9B0 (/IDA) Q9VW83 (/IDA)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
4 M9PD17 (/IDA) Q7K0T0 (/IDA) Q9U9B0 (/IDA) Q9VW83 (/IDA)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Negative regulation of organ growth GO:0046621
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
4 M9PD17 (/IGI) Q7K0T0 (/IGI) Q9U9B0 (/IGI) Q9VW83 (/IGI)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Cellular response to chloroquine GO:1902350
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
4 M9PD17 (/IMP) Q7K0T0 (/IMP) Q9U9B0 (/IMP) Q9VW83 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q7K0T0 (/IMP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 A0A1D8PMB6 (/IMP)
Negative regulation of signal transduction GO:0009968
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
1 Q9U9B0 (/TAS)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9VW83 (/IGI)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 Q9U9B0 (/TAS)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PMB6 (/IMP)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
1 Q7K0T0 (/IGI)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q9UUG9 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q9UUG9 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PMB6 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
1 A0A1D8PMB6 (/IMP)
Filamentous growth of a population of unicellular organisms in response to chemical stimulus GO:0036171
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.
1 A0A1D8PMB6 (/IMP)
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
1 Q9VW83 (/IGI)
Positive regulation of lipophagy GO:1904504
Any process that activates or increases the frequency, rate or extent of lipophagy.
1 Q9VW83 (/IMP)
Positive regulation of TORC2 signaling GO:1904515
Any process that activates or increases the frequency, rate or extent of TORC2 signaling.
1 Q9VW83 (/IGI)
Positive regulation of TORC2 signaling GO:1904515
Any process that activates or increases the frequency, rate or extent of TORC2 signaling.
1 Q9VW83 (/IMP)
Positive regulation of leucine import across plasma membrane GO:1905534
Any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane.
1 Q9UUG9 (/IMP)
Positive regulation of L-arginine import across plasma membrane GO:1905589
Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane.
1 Q9UUG9 (/IGI)
Positive regulation of L-arginine import across plasma membrane GO:1905589
Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane.
1 Q9UUG9 (/IMP)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
1 Q9UUG9 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TSC1-TSC2 complex GO:0033596
A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
5 M9PD17 (/IPI) Q7K0T0 (/IPI) Q9U9B0 (/IPI) Q9UUG9 (/IPI) Q9VW83 (/IPI)
TSC1-TSC2 complex GO:0033596
A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
2 Q7K0T0 (/IDA) Q9VW83 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UUG9 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9UUG9 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q7K0T0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9UUG9 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9VW83 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9U9B0 (/TAS)
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