The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rap/Ran-GAP
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Ral GTPase-activating protein subunit alpha-1 isof...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
7 A3KGS3 (/ISS) O55007 (/ISS) Q2PPJ7 (/ISS) Q54VB2 (/ISS) Q6GYP7 (/ISS) Q6GYQ0 (/ISS) Q9VB98 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P86411 (/IPI) Q6GYQ0 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 A3KGS3 (/ISO) Q6GYP7 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 A3KGS3 (/ISS) Q2PPJ7 (/ISS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 P86411 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 A3KGS3 (/IGI)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q6GYP7 (/ISA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 A3KGS3 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
8 A0A2R8Q8N1 (/IMP) A0A2R8QSV2 (/IMP) C0SU61 (/IMP) C0SU62 (/IMP) F1QRR8 (/IMP) F1R073 (/IMP) X1WBQ5 (/IMP) X1WFB2 (/IMP)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
5 A3KGS3 (/ISS) O55007 (/ISS) Q2PPJ7 (/ISS) Q6GYP7 (/ISS) Q6GYQ0 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q6GYP7 (/IDA)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 V6CLC2 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 V6CLC2 (/IMP)
Ral protein signal transduction GO:0032484
A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.
1 A3KGS3 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 A3KGS3 (/IMP)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q54VB2 (/IMP)
Regulation of exocyst localization GO:0060178
Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.
1 A3KGS3 (/IMP)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
1 P86411 (/IDA)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
1 A3KGS3 (/IGI)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
1 A3KGS3 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 A3KGS3 (/ISS) O55007 (/ISS) P86411 (/ISS) Q6GYQ0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O55007 (/ISS) Q6GYQ0 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q2PPJ7 (/IDA) Q6GYP7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 H7C1F9 (/IDA) Q2PPJ7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 H7C1F9 (/IDA) Q2PPJ7 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q2PPJ7 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6GYP7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 A3KGS3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A3KGS3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A3KGS3 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A3KGS3 (/ISO)
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