# STOCKHOLM 1.0 #=GF ID 3.30.50.10/FF/000044 #=GF DE retinoic acid receptor beta isoform X4 #=GF AC 3.30.50.10/FF/000044 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 91.160 #=GS Q15156/418-514 AC Q15156 #=GS Q15156/418-514 OS Homo sapiens #=GS Q15156/418-514 DE PML-RAR protein #=GS Q15156/418-514 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS Q15156/418-514 DR GO; GO:0003700; GO:0005515; GO:0031264; GO:2001237; #=GS Q14267/175-275 AC Q14267 #=GS Q14267/175-275 OS Homo sapiens #=GS Q14267/175-275 DE Estrogen receptor-related protein #=GS Q14267/175-275 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS Q14267/175-275 DR GO; GO:0003677; GO:0003700; #=GS A0A286YCH1/76-175 AC A0A286YCH1 #=GS A0A286YCH1/76-175 OS Mus musculus #=GS A0A286YCH1/76-175 DE Retinoic acid receptor beta #=GS A0A286YCH1/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Mus; Mus; Mus musculus; #=GS A0A0A0VEB4/219-315 AC A0A0A0VEB4 #=GS A0A0A0VEB4/219-315 OS Homo sapiens #=GS A0A0A0VEB4/219-315 DE GTF2I-RARA fusion protein #=GS A0A0A0VEB4/219-315 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; #=GS W4YNJ8/188-282 AC W4YNJ8 #=GS W4YNJ8/188-282 OS Strongylocentrotus purpuratus #=GS W4YNJ8/188-282 DE Uncharacterized protein #=GS W4YNJ8/188-282 DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; #=GS C3ZPQ2/8-108 AC C3ZPQ2 #=GS C3ZPQ2/8-108 OS Branchiostoma floridae #=GS C3ZPQ2/8-108 DE Uncharacterized protein #=GS C3ZPQ2/8-108 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GS F7B3X7/21-111 AC F7B3X7 #=GS F7B3X7/21-111 OS Xenopus tropicalis #=GS F7B3X7/21-111 DE Nuclear receptor subfamily 1 group I member 3 #=GS F7B3X7/21-111 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana; Xenopus tropicalis; #=GS F1N7B3/13-123 AC F1N7B3 #=GS F1N7B3/13-123 OS Bos taurus #=GS F1N7B3/13-123 DE RAR related orphan receptor C #=GS F1N7B3/13-123 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Ruminantia; Pecora; Bovidae; Bovinae; Bos; Bos taurus; #=GS A0A2Y9FX37/76-175 AC A0A2Y9FX37 #=GS A0A2Y9FX37/76-175 OS Trichechus manatus latirostris #=GS A0A2Y9FX37/76-175 DE retinoic acid receptor beta isoform X3 #=GS A0A2Y9FX37/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Afrotheria; Sirenia; Trichechidae; Trichechus; Trichechus manatus; Trichechus manatus latirostris; #=GS A0A1S3WKU5/22-132 AC A0A1S3WKU5 #=GS A0A1S3WKU5/22-132 OS Erinaceus europaeus #=GS A0A1S3WKU5/22-132 DE nuclear receptor ROR-gamma isoform X2 #=GS A0A1S3WKU5/22-132 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae; Erinaceus; Erinaceus europaeus; #=GS S7NJ97/243-356 AC S7NJ97 #=GS S7NJ97/243-356 OS Myotis brandtii #=GS S7NJ97/243-356 DE Nuclear receptor ROR-gamma #=GS S7NJ97/243-356 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae; Myotis; Myotis brandtii; #=GS A0A455AX52/83-179 AC A0A455AX52 #=GS A0A455AX52/83-179 OS Physeter catodon #=GS A0A455AX52/83-179 DE retinoic acid receptor alpha isoform X1 #=GS A0A455AX52/83-179 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Odontoceti; Physeteridae; Physeter; Physeter catodon; #=GS A0A2U3ZX54/76-175 AC A0A2U3ZX54 #=GS A0A2U3ZX54/76-175 OS Odobenus rosmarus divergens #=GS A0A2U3ZX54/76-175 DE retinoic acid receptor beta isoform X4 #=GS A0A2U3ZX54/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus; Odobenus rosmarus; Odobenus rosmarus divergens; #=GS H0W6W9/8-118 AC H0W6W9 #=GS H0W6W9/8-118 OS Cavia porcellus #=GS H0W6W9/8-118 DE Uncharacterized protein #=GS H0W6W9/8-118 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Hystricomorpha; Caviidae; Cavia; Cavia porcellus; #=GS A0A1S3F4L0/22-135 AC A0A1S3F4L0 #=GS A0A1S3F4L0/22-135 OS Dipodomys ordii #=GS A0A1S3F4L0/22-135 DE nuclear receptor ROR-gamma isoform X3 #=GS A0A1S3F4L0/22-135 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Castorimorpha; Heteromyidae; Dipodomyinae; Dipodomys; Dipodomys ordii; #=GS A0A3Q0CB57/22-136 AC A0A3Q0CB57 #=GS A0A3Q0CB57/22-136 OS Mesocricetus auratus #=GS A0A3Q0CB57/22-136 DE nuclear receptor ROR-gamma isoform X5 #=GS A0A3Q0CB57/22-136 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Cricetidae; Cricetinae; Mesocricetus; Mesocricetus auratus; #=GS A0A3Q0E3Q6/76-175 AC A0A3Q0E3Q6 #=GS A0A3Q0E3Q6/76-175 OS Carlito syrichta #=GS A0A3Q0E3Q6/76-175 DE retinoic acid receptor beta isoform X4 #=GS A0A3Q0E3Q6/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae; Carlito; Carlito syrichta; #=GS A0A2Y9G6E7/76-175 AC A0A2Y9G6E7 #=GS A0A2Y9G6E7/76-175 OS Neomonachus schauinslandi #=GS A0A2Y9G6E7/76-175 DE retinoic acid receptor beta isoform X4 #=GS A0A2Y9G6E7/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Carnivora; Caniformia; Phocidae; Neomonachus; Neomonachus schauinslandi; #=GS A0A2Y9KP25/76-175 AC A0A2Y9KP25 #=GS A0A2Y9KP25/76-175 OS Enhydra lutris kenyoni #=GS A0A2Y9KP25/76-175 DE retinoic acid receptor beta isoform X3 #=GS A0A2Y9KP25/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Lutrinae; Enhydra; Enhydra lutris; Enhydra lutris kenyoni; #=GS A0A340XWH4/76-176 AC A0A340XWH4 #=GS A0A340XWH4/76-176 OS Lipotes vexillifer #=GS A0A340XWH4/76-176 DE retinoic acid receptor beta isoform X3 #=GS A0A340XWH4/76-176 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Odontoceti; Lipotidae; Lipotes; Lipotes vexillifer; #=GS A0A2K5DT54/22-132 AC A0A2K5DT54 #=GS A0A2K5DT54/22-132 OS Aotus nancymaae #=GS A0A2K5DT54/22-132 DE Uncharacterized protein #=GS A0A2K5DT54/22-132 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Aotidae; Aotus; Aotus nancymaae; #=GS G1PA29/83-179 AC G1PA29 #=GS G1PA29/83-179 OS Myotis lucifugus #=GS G1PA29/83-179 DE Retinoic acid receptor alpha #=GS G1PA29/83-179 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae; Myotis; Myotis lucifugus; #=GS C3YIU7/29-132 AC C3YIU7 #=GS C3YIU7/29-132 OS Branchiostoma floridae #=GS C3YIU7/29-132 DE Uncharacterized protein #=GS C3YIU7/29-132 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GS C3YIU8/615-716 AC C3YIU8 #=GS C3YIU8/615-716 OS Branchiostoma floridae #=GS C3YIU8/615-716 DE Uncharacterized protein #=GS C3YIU8/615-716 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GS C3Z7Z3/597-702 AC C3Z7Z3 #=GS C3Z7Z3/597-702 OS Branchiostoma floridae #=GS C3Z7Z3/597-702 DE Uncharacterized protein #=GS C3Z7Z3/597-702 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GS A0A3Q0CHH9/22-136 AC A0A3Q0CHH9 #=GS A0A3Q0CHH9/22-136 OS Mesocricetus auratus #=GS A0A3Q0CHH9/22-136 DE nuclear receptor ROR-gamma isoform X4 #=GS A0A3Q0CHH9/22-136 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Cricetidae; Cricetinae; Mesocricetus; Mesocricetus auratus; #=GS A0A3Q0D498/76-175 AC A0A3Q0D498 #=GS A0A3Q0D498/76-175 OS Mesocricetus auratus #=GS A0A3Q0D498/76-175 DE retinoic acid receptor beta isoform X4 #=GS A0A3Q0D498/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Cricetidae; Cricetinae; Mesocricetus; Mesocricetus auratus; #=GS A0A1S2ZCC4/76-175 AC A0A1S2ZCC4 #=GS A0A1S2ZCC4/76-175 OS Erinaceus europaeus #=GS A0A1S2ZCC4/76-175 DE retinoic acid receptor beta isoform X4 #=GS A0A1S2ZCC4/76-175 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae; Erinaceus; Erinaceus europaeus; #=GS A0A455B9X6/80-176 AC A0A455B9X6 #=GS A0A455B9X6/80-176 OS Physeter catodon #=GS A0A455B9X6/80-176 DE retinoic acid receptor alpha isoform X2 #=GS A0A455B9X6/80-176 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Odontoceti; Physeteridae; Physeter; Physeter catodon; #=GS A0A3Q0D995/83-182 AC A0A3Q0D995 #=GS A0A3Q0D995/83-182 OS Mesocricetus auratus #=GS A0A3Q0D995/83-182 DE retinoic acid receptor beta isoform X2 #=GS A0A3Q0D995/83-182 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Cricetidae; Cricetinae; Mesocricetus; Mesocricetus auratus; #=GS A0A455AW60/30-126 AC A0A455AW60 #=GS A0A455AW60/30-126 OS Physeter catodon #=GS A0A455AW60/30-126 DE retinoic acid receptor alpha isoform X3 #=GS A0A455AW60/30-126 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Odontoceti; Physeteridae; Physeter; Physeter catodon; #=GF SQ 31 Q15156/418-514 ------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPE-----CSESYT--------------- Q14267/175-275 AMESAKET-RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHST------PATLQWL--------------- A0A286YCH1/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ A0A0A0VEB4/219-315 ------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPE-----CSESYT--------------- W4YNJ8/188-282 ---GERGLDIPCQVCGDRSSGRHYGVYSCDGCRGFFKRSVRRNLAYVCRDGGRCIVNVPRRNQCQACRYRKCLAVNMNRDAVQHERAPRC--------FARPYNIP----------------- C3ZPQ2/8-108 --PRLTEP-ELCRVCGDRASGYHYNVLSCEGCKGFFRRSITKNAVYKCKYGGKCEMDMYMRRKCQECRLRKCREVGMLEECLLSEDQIKAKRLRRQST--DPASPA----------------- F7B3X7/21-111 DNDPDTEE-KLCSVCGDKANGYHFHVLTCEGCKGFFRRSVSKGLHFTCPFTRSCPITKAKRRRCQACRLHKCFSVGMRKDSIMQAKG----------------------FQLCQ--------- F1N7B3/13-123 ---AQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQRQQQQREQAA-- A0A2Y9FX37/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ A0A1S3WKU5/22-132 -HTSQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQNCSIAYSCTRQQNCPIDRASRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQRQRDPAVK---- S7NJ97/243-356 --TSQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQHCGVAYACTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQRQLQQQQQQQQQQREQR A0A455AX52/83-179 ------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEAPKPE-----CSESYT--------------- A0A2U3ZX54/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ H0W6W9/8-118 --CAQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCHVVYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQQQQLQREQV--- A0A1S3F4L0/22-135 -HTSQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQQQQQQQQQEQI- A0A3Q0CB57/22-136 -HTSQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQQQQQQQQQQQVA A0A3Q0E3Q6/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ A0A2Y9G6E7/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ A0A2Y9KP25/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CAESYEMTA------------ A0A340XWH4/76-176 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQEX--XXXTESYEM-------------- A0A2K5DT54/22-132 -HTSQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQRQQPAVKT---- G1PA29/83-179 ------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEAPKPE-----CSESYT--------------- C3YIU7/29-132 ----ELAA-GDCLVCGDKASGFHYGVFSCEGCKGFFRRSVTRGHVKACRWGNQCSMDLYTRRRCPECRLRSCKAAGMRPDCLLTQAQCRSKLLWRKSI--APKPVKSERAA------------ C3YIU8/615-716 --PQDVES-GNCLVCGEKASGFHYGVFSCESCKGFFRRSVHKGSVKVCKFGNRCCLNPSTKRSCADCRLRLCKAAGMRPDCLLTDAQRRSKSLWRHH---RPASQSSN--------------- C3Z7Z3/597-702 --EGKPGD-KTCLICGDRATGLHYGIVSCEGCKGFFKRSICNKRVYRCSRNKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSI-----GPVEISEEEIERIM--------- A0A3Q0CHH9/22-136 -HTSQIEV-IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSL------HAEVQKQLQQQQQQQQQQQQVA A0A3Q0D498/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ A0A1S2ZCC4/76-175 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKPE-----CTESYEMTA------------ A0A455B9X6/80-176 ------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEAPKPE-----CSESYT--------------- A0A3Q0D995/83-182 ------RVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQE-----CTESYEMTA------------ A0A455AW60/30-126 ------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEAPKPE-----CSESYT--------------- #=GC scorecons 000111541459379587689498783598898899899454544749454569475534867974998679455895565643564365532431100001433423112000000000000 #=GC scorecons_70 ___________*_**_*****_****__***********______*_*_____*_*____*****_******___**__*_*______*__________________________________ #=GC scorecons_80 ___________*_**_**_**_****__***********______*_*_____*_*____*__**_***_**___**______________________________________________ #=GC scorecons_90 ___________*__*_*___*_**_*__***********________*_____*______*__*__***__*___**______________________________________________ //