# STOCKHOLM 1.0
#=GF ID 1.20.1730.10/FF/000022
#=GF DE Sensor histidine kinase
#=GF AC 1.20.1730.10/FF/000022
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 76.066
#=GS Q9KV54/15-539              AC Q9KV54
#=GS Q9KV54/15-539              OS Vibrio cholerae O1 biovar El Tor str. N16961
#=GS Q9KV54/15-539              DE Sensor histidine kinase
#=GS Q9KV54/15-539              DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GS Q9KV54/15-539              DR GO; GO:0000155; GO:0000160; 
#=GS Q9HYX0/34-561              AC Q9HYX0
#=GS Q9HYX0/34-561              OS Pseudomonas aeruginosa PAO1
#=GS Q9HYX0/34-561              DE Probable two-component sensor
#=GS Q9HYX0/34-561              DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; Pseudomonas aeruginosa group; Pseudomonas aeruginosa; 
#=GS Q9HYX0/34-561              DR GO; GO:0000155; GO:0000160; GO:1900376; 
#=GS Q89HV0/34-475_508-564      AC Q89HV0
#=GS Q89HV0/34-475_508-564      OS Bradyrhizobium diazoefficiens USDA 110
#=GS Q89HV0/34-475_508-564      DE Two-component hybrid sensor and regulator
#=GS Q89HV0/34-475_508-564      DR ORG; Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium; Bradyrhizobium diazoefficiens; 
#=GS Q8EDK4/26-527              AC Q8EDK4
#=GS Q8EDK4/26-527              OS Shewanella oneidensis MR-1
#=GS Q8EDK4/26-527              DE Proline-responsive two component signal transduction system hybrid histidine kinase/resposne regulator PrlS
#=GS Q8EDK4/26-527              DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; Shewanellaceae; Shewanella; Shewanella oneidensis; 
#=GS A0A0R3DSL0/35-470_503-558  AC A0A0R3DSL0
#=GS A0A0R3DSL0/35-470_503-558  OS Bradyrhizobium manausense
#=GS A0A0R3DSL0/35-470_503-558  DE Histidine kinase
#=GS A0A0R3DSL0/35-470_503-558  DR ORG; Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium; Bradyrhizobium manausense; 
#=GS A0A2A6PIQ3/53-490_523-578  AC A0A2A6PIQ3
#=GS A0A2A6PIQ3/53-490_523-578  OS Bradyrhizobium sp. Y36
#=GS A0A2A6PIQ3/53-490_523-578  DE Hybrid sensor histidine kinase/response regulator
#=GS A0A2A6PIQ3/53-490_523-578  DR ORG; Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium; Bradyrhizobium sp. Y36; 
#=GS A0A127MXE9/34-556          AC A0A127MXE9
#=GS A0A127MXE9/34-556          OS Pseudomonas citronellolis
#=GS A0A127MXE9/34-556          DE Sensory/regulatory protein RpfC
#=GS A0A127MXE9/34-556          DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; Pseudomonas aeruginosa group; Pseudomonas citronellolis; 
#=GS A0A0K9UMC5/15-539          AC A0A0K9UMC5
#=GS A0A0K9UMC5/15-539          OS Vibrio cholerae 2740-80
#=GS A0A0K9UMC5/15-539          DE Sensory transduction protein kinase
#=GS A0A0K9UMC5/15-539          DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GS A0A0H3Q8J3/15-539          AC A0A0H3Q8J3
#=GS A0A0H3Q8J3/15-539          OS Vibrio cholerae B33
#=GS A0A0H3Q8J3/15-539          DE Sensor histidine kinase
#=GS A0A0H3Q8J3/15-539          DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GS B2ZRD5/15-539              AC B2ZRD5
#=GS B2ZRD5/15-539              OS Vibrio cholerae
#=GS B2ZRD5/15-539              DE Histidine kinase
#=GS B2ZRD5/15-539              DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GS A0A0X1L4S9/15-539          AC A0A0X1L4S9
#=GS A0A0X1L4S9/15-539          OS Vibrio cholerae MO10
#=GS A0A0X1L4S9/15-539          DE Sensor histidine kinase
#=GS A0A0X1L4S9/15-539          DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GS C3LQQ9/15-539              AC C3LQQ9
#=GS C3LQQ9/15-539              OS Vibrio cholerae M66-2
#=GS C3LQQ9/15-539              DE Sensor histidine kinase
#=GS C3LQQ9/15-539              DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GS A0A0H6INY1/1-506           AC A0A0H6INY1
#=GS A0A0H6INY1/1-506           OS Vibrio cholerae
#=GS A0A0H6INY1/1-506           DE Sensor histidine kinase
#=GS A0A0H6INY1/1-506           DR ORG; Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio; Vibrio cholerae; 
#=GF SQ 13
Q9KV54/15-539                      ----GVLFLIAWYGDRQTRWLA----NWRPWIYSLSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----EL------------
Q9HYX0/34-561                      ------------------------SPRLRAWVYSLSLAVYCTSWTFFGAVGQATDQLWSFLPIYLGPVLLMLFAPWVLQKMIMISKQENITSIADFIAARYGKSQALAVVVALICMVGVLPYIALQLKGIVLGVNLLIGSGADSTGTRA---QDTALIVSLVLALFTIVFGTRSLDVTEHHRGMVLAIAFESLVKLTAFLAVGIFATFGLYDGFADLFSQARAAPQLA---DYWEETVHWPAMLLQTGVAMTAIMCLPRQFHVTVVENIEPRDLNLARWVFPIYLVLAALFVVPIALAGQLHLPAGVMPDSFVISLPLAEAHPALALLAFIGGASAATGMVIVASVALSTMVSNDMLLPWLLRRREKDTERPF-EAFRHWLLTVRRVSIAVILLLAYVAYRLLGSSASLATIGQIAFAAIAQLGPAMIGALYWKQANRRGVFAGLAAGSLLWAYTLVLPVVAKGLGWPLERIPGLTWLASNP---FGLPIEPLTQGVLISLVGNFALFGLVSVLSRTRVSEHWQASRFIGQEI-----SQRQNSRFMLAVQVEDLLMLAARFVGEER
Q89HV0/34-475_508-564              RSAGGPLV-------SPNSWAA-------AISYCLTLAVYNTSWSFYGSVGRAATSGLDFATIYIGPTLVLLFGQTLLSKVIAIAKAQNVTSVSDFIAARYGKSQVLAAFVTLASLLGVLPYIALQLKAVGKSFDYLILQPERAGGEALRFWQDSAFGVAASMALFAIVFGVRHVHASEHHRGLMLAIAFESVVKLIAFLIVALFVLFGLSGGPGALLTQFQSDPQLTGILSFDPMQPVWPSTII---ISAIAFLCLPQAFHVAVVENEAPVHTRTAAWLYPAYLALFSLLILPIAAAGLTRFGAMMDPDTYVISLPIAADASTVSLIAFLGGLSAATGMVIMTSVALSTMLCNDVIMPLLLRSRFF-GLRAQSRPMTSVLVAVRRLSILGILLLAYLTHRLVNQAYPLTVIGLLSFVAVAQFGPAFVGGLYWPRANKVGASVGIAAGFCIWSYTLLLP-----------------------------SLDPISHATLWSLAANLVCFLAFSTLGRQSTVERNQAAAFADGVV--REMVPKLSSRVVV-------------------
Q8EDK4/26-527                      -----------------ERWFSGVTKKLQVVIYGLSLAVYCSSWSFLGTVGQSAKDFWSFIPIFVGPILIFTLGFGMLRKMVLVSKAQNITSVADFIAARYGKSQTLAAIVTLIAMFGIMPYIALQLKAMVFSLNLFQPADDPLNGVTI------ALLITALLAIFAILFGTRKLDATEHNPGMMLAIAFESLVKLAAFLLVGIVISFGVFDGFGDIWQQASD------KSLIHHPNPRIETLMPELLVGMAAFLCMPRQFHVMVVECADESVLSKGRWLFPLYLALFGLFVGPLALAGKLILGDSVAADTYVINLPLALDHPLLAVIALLGTLSAATGMVIVAVVTISVMVSNEWLVPVVLRTGNI-REKNF-SQFSQMLLNARRLAIVIILGLGYGSYLALADSDSLSHLGMLSFGAFAQLAPALVGGLYWKHGNRAGVFLGLSVGFSLWFYIML-------SGMTGNQSPAALMSSNID---LLDAITPNVRDALTALFANIACYVLGSIWFRAGVAERIQASAFVSPGK-LKNNASKKSG-----------------------
A0A0R3DSL0/35-470_503-558          ---------------SPKSWAA-------AISYCLTLAVYNTSWSFYGSVGRAATSGLDFATIYIGPTLVLLFGQKLLGKLIAIAKAQNVTSIADFIAARYGKSQVLAAFVTLASLLGVLPYIALQLKAVGKSFDYLILQPERASGEALRFWQDSAFGVAASMALFAIVFGVRHVHASEHHRGLMLAIAFESVVKLIAFLVVALFVLFGLSGGPAALLSQLSSDPQLAGILAFDPAQPVWPSTII---ISAIAFLCLPQAFHVVVVENESPGHTRTAAWLYPAYLALFSLLILPIAAAGLARFGAMTDPDTYVISLPIAADAGTISLIAFLGGLSAATGMVIMTSVALSTMLCNDVIMPLLLRSRFF-GLRAQSRPVTSVLMTVRRLSILCILLLAYLMHRLVNQAYPLTVIGLLSFVAVAQFGPAFVGGLFWQRANKIGASMGIAAGFLIWAYTLLLP-----------------------------SAAPISHATLWSLAANIICFVAFSLLGRQTTVERNQAAAFADGVV--RDTVPKLSSRVVVR------------------
A0A2A6PIQ3/53-490_523-578          ------LV-------SPKSWAA-------AISYCLTLAVYNTSWSFYGSVGRAATSGLDFATIYIGPTLVLLFGQRLLSKVIAIAKAQNVTSIADFIAARYGKSQVLAAFVTLASLLGVLPYIALQLKAVGKSFDYLILQPERAGGEALRFWQDSAFGVAASMALFAIVFGVRHVHASEHHRGLMLAIAFESVVKLLAFLIVALFVLFGLSGGPATLLSQFQSDQQLAGILSFDPTQPVWPATIV---ISAIAFLCLPQAFHVAVVENESPNHTRTAAWLYPAYLALFSLLILPIAAAGLARFGGMMDPDTYVISLPIAADAGTISLIAFLGGLSAATGMVIMTSVALSTMLCNDVIMPLLLRSRVF-GLRAQSRPMTSVLVAVRRLSILGILLLAYLMHRLVNQSYPLTVIGLLSFVAVAQFGPAFVGGLFWPRANKAGASLGIAAGFFIWAYTLLLP-----------------------------SAAPISHATLWSLGANLVCFLVVSALGRQSTVERNQAAAFADGVV--RETIPKLSSRVLVR------------------
A0A127MXE9/34-556                  ------------------------SPRLRAWVYSLSLAVYCTSWTFFGAVGQAAGQLWSFLPIYLGPVLLMLFAPWVLQKMIMISKQENITSIADFIAARYGKSQALAVVVALICVVCVLPYIALQLKGIVLGVNLLIGAGADSGGSRA---QDTALIVSLVLALFTIVFGTRSLDVTEHHRGMVLAIAFESLVKLTAFLAVGIFVTFGLYDGFGDLFDKARDAPQLA---EYWQETVHWPAMLLQTGVAMTAIMCLPRQFHVLVVENIEPRDLNLARWVFPAYLVLAALFVVPIALAGQMQLPAGVIPDSFVISLPLAEAHPALALLAFIGGASAATGMVIVASVALSTMVSNDMLLPWLLRRKGTDAEQPF-EVFRHWLLTVRRVSIALILLLAYVSYRLLGSTASLATIGQIAFAAIAQLGPAMIGALYWKQANRRGVFAGLAAGAALWAYTLVLPVIARSLGWPLEHFPGLTWLAAHP---FGINIEPLTLGVLLSLIGNFALFGLVSVFSRTRVSEHWQASRFIGQEI-----SQRLSSRSMLAVQLEDLLMLAARF-----
A0A0K9UMC5/15-539                  ----GVLFLIAWYGDRQTRWLA----NWRPWIYSLSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----EL------------
A0A0H3Q8J3/15-539                  ----GVLFLIAWYGDRQTRWLA----NWRPWIYSLSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----EL------------
B2ZRD5/15-539                      ----GVLFLIAWYGDRQTRWLA----NWRPWIYSLSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----EL------------
A0A0X1L4S9/15-539                  ----GVLFLIAWYGDRQTRWLA----NWRPWIYSLSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----EL------------
C3LQQ9/15-539                      ----GVLFLIAWYGDRQTRWLA----NWRPWIYSLSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----EL------------
A0A0H6INY1/1-506                   ----------------------------------MSIAVYCTSWTFYGTVGQASVNPWSFLPIYIAPILMFVFGWRVLARLILIAKREHITSLADFIAARYGKSQGLAVAVTVIAVLGILPYIALQLRGITMGLNIVAPDLMTVYGYQE---SHVSWFVVLALALFTMLFGTRHIDNTEHHRGMMMAIAFESIVKLVAFLCVGVFIAYLAWRTDG---------LELSTIAASTYQAPNWPTLLIHTLLTMIAIVCLPRQFHTMVVENERPQDLHTARWLFPVYLLLMSLFVLPIAWTGQGLLP-NTSPDTFVISLPVFAGAHDIALLAFLGGTSAASGMVIVSTIALAIMVSNDLVMPLLLRRMRL-SQRTH-RHFSGLLVVIRRTLILLLLFGAWGFYLVLDSIPSLSAIGFLSFSAITQFAPAIFGGMYWREGNRKGVYVGLAVGFTLWLITLM---SATDMLAGDASNNVLLWVITPPDWLVALGLKSADWGMLLSVTLNTLCYIGVSLVTRASLSERLQAAAFVGTPLPENENMSLYQSRVTVG----ELEMLASRF-----
#=GC scorecons                     000011210000000122242300002124347486699967996969599675343569569866959555773469475858694667995799999999999499649766556778999999976644656454443344393430004436438454797966699695564699779776999999599949993965764745345361211211113574242443334637755652325466955989669954999753735645769779599494696759793695336513537977997995455543667697797499969999655777659669845695799543404474405464449646994495369547543745645436954794779496696699459767954697496559676963694578511013122212222222323222231112224546443549476449446743594449454597399669554341134345435775353000023000000000000
#=GC scorecons_70                  ________________________________*_******_***_***_****_____**_****_*_*___**___*_*_*_***_*_***_************_**__****__************_*____*__________*____________*___***********__*_***************_***_***_**_**_*______*___________*__________*_**___________*__****_**__****__*_____*_****_**_*__***_***_**___*_____*********_______*********_***_*****__***__*****__**_***_______*_________*___**__*__**__*___*__*____**__**_***_*****_**__*****___**_**__***_**_**__**_________________________________________*_**__*__**___*___*____**_*****_______________**______________________
#=GC scorecons_80                  ________________________________*_*__***_***_*_*_**_*______*__**__*_*___*____*___*_*_*___***_************_**__**_____*_********__________________*____________*____***___**_*_____*****_*_******_***_***_*__*__*________________________________*___________*__***__**__****__*_____*_****_**_*__*_*_***__*_________**_******_________*_*****_***_****____**__*__**___*_***_______*_________*___**__*___*__*___*________*__**_*_*_*__*__**__*__**___**_*___*_*_*___*__**_________________________________________*_*___*___*___*___*____**_**__*_______________*_______________________
#=GC scorecons_90                  __________________________________*__***__**_*_*_**________*__**__*_*________*___*_*_*____**__***********_**__*________********__________________*____________*____*_*___**_*_____**__*___******_***_***_*__________________________________________________*__***__**__***___________*__*_**_*__*___*_*__*__________*__**_**___________*__*__***_****________*__**___*__**_________________*___**__*___*_______________*___*___*_*__*__**__*___*___*__*___*___*___*___*_________________________________________*_____*_______*___*____*__**__*_______________________________________
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