The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"FF domain
".
FunFam 17: Rho GTPase activating protein 35
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
6 | P81128 (/IDA) Q91YM2 (/IDA) Q91YM2 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
5 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q91YM2 (/ISS) Q91YM2 (/ISS) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
5 | Q91YM2 (/TAS) Q91YM2 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) |
|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
5 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q91YM2 (/ISS) Q91YM2 (/ISS) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
3 | Q9NRY4 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q9NRY4 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | Q9NRY4 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
3 | Q9NRY4 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) |
|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
3 | Q9NRY4 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
1 | P81128 (/IPI) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | P81128 (/IDA) |
There are 49 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Central nervous system neuron axonogenesis GO:0021955
Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Establishment or maintenance of actin cytoskeleton polarity GO:0030950
Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Cellular response to extracellular stimulus GO:0031668
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Wound healing, spreading of cells GO:0044319
The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Positive regulation of cilium assembly GO:0045724
Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
4 | P83509 (/ISS) P83509 (/ISS) Q91YM2 (/ISS) Q91YM2 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q9NRY4 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
3 | Q9NRY4 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
3 | Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q9NRY4 (/IDA) Q9NRY4 (/IDA) Q9NRY4 (/IDA) |
|
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
|
3 | Q9NRY4 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q91YM2 (/TAS) Q91YM2 (/TAS) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | Q91YM2 (/IDA) Q91YM2 (/IDA) |
|
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Regulation of actin polymerization or depolymerization GO:0008064
Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
2 | Q91YM2 (/IDA) Q91YM2 (/IDA) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | Q91YM2 (/IGI) Q91YM2 (/IGI) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Central nervous system neuron axonogenesis GO:0021955
Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Establishment or maintenance of actin cytoskeleton polarity GO:0030950
Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Cellular response to extracellular stimulus GO:0031668
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
2 | Q91YM2 (/IDA) Q91YM2 (/IDA) |
|
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
|
2 | Q91YM2 (/IGI) Q91YM2 (/IGI) |
|
Regulation of eye photoreceptor cell development GO:0042478
Any process that modulates the frequency, rate or extent of eye photoreceptor development.
|
2 | P83509 (/NAS) P83509 (/NAS) |
|
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Negative regulation of vascular permeability GO:0043116
Any process that reduces the extent to which blood vessels can be pervaded by fluid.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
Wound healing, spreading of cells GO:0044319
The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Positive regulation of cilium assembly GO:0045724
Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P83509 (/ISS) P83509 (/ISS) |
|
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | Q91YM2 (/IMP) Q91YM2 (/IMP) |
|
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
1 | P81128 (/IDA) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
6 | P81128 (/ISS) P83509 (/ISS) P83509 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) Q9NRY4 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q9NRY4 (/IC) Q9NRY4 (/IC) Q9NRY4 (/IC) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q9NRY4 (/TAS) Q9NRY4 (/TAS) Q9NRY4 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q91YM2 (/IDA) Q91YM2 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q91YM2 (/ISO) Q91YM2 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | Q91YM2 (/IDA) Q91YM2 (/IDA) |
|
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
2 | Q91YM2 (/IDA) Q91YM2 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P81128 (/IDA) |
