CATH Domain 5mqyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cathepsin S

Enzyme Information

3.4.22.15

Cathepsin L.

based on mapping to UniProt P07711

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07711

CATL1_HUMAN

Homo sapiens

Cathepsin L1

PDB Structure

PDB	5MQY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors. Kuhn, B., Tichy, M., Wang, L., Robinson, S., Martin, R.E., Kuglstatter, A., Benz, J., Giroud, M., Schirmeister, T., Abel, R., Diederich, F., Hert, J. J. Med. Chem.