CATH Domain 5emnA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.30	Elongation Factor Tu (Ef-tu); domain 3
	2.40.30.10	Translation factors

Domain Context

CATH Clusters

Superfamily	Translation factors
Functional Family	NADPH--cytochrome P450 reductase

Enzyme Information

1.6.2.4

NADPH--hemoprotein reductase.

based on mapping to UniProt P16435

NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.

-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

UniProtKB Entries (1)

P16435

NCPR_HUMAN

Homo sapiens

NADPH--cytochrome P450 reductase

PDB Structure

PDB	5EMN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. McCammon, K.M., Panda, S.P., Xia, C., Kim, J.J., Moutinho, D., Kranendonk, M., Auchus, R.J., Lafer, E.M., Ghosh, D., Martasek, P., Kar, R., Masters, B.S., Roman, L.J. J.Biol.Chem.