CATH Domain 4wq6B02

Superfamily	Aldolase class I
Functional Family

2.4.2.12

Nicotinamide phosphoribosyltransferase.

based on mapping to UniProt P43490

Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

NAMPT_HUMAN

Homo sapiens

Nicotinamide phosphoribosyltransferase

PDB	4WQ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Zak, M., Liederer, B.M., Sampath, D., Yuen, P.W., Bair, K.W., Baumeister, T., Buckmelter, A.J., Clodfelter, K.H., Cheng, E., Crocker, L., Fu, B., Han, B., Li, G., Ho, Y.C., Lin, J., Liu, X., Ly, J., O'Brien, T., Reynolds, D.J., Skelton, N., Smith, C.C., Tay, S., Wang, W., Wang, Z., Xiao, Y., Zhang, L., Zhao, G., Zheng, X., Dragovich, P.S. Bioorg.Med.Chem.Lett.