CATH Domain 4p59H02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Immunoglobulin heavy constant gamma 1

Enzyme Information

UniProtKB Entries (1)

ERBB3_HUMAN

Homo sapiens

Receptor tyrosine-protein kinase erbB-3

PDB Structure

PDB	4P59
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Garner, A.P., Bialucha, C.U., Sprague, E.R., Garrett, J.T., Sheng, Q., Li, S., Sineshchekova, O., Saxena, P., Sutton, C.R., Chen, D., Chen, Y., Wang, H., Liang, J., Das, R., Mosher, R., Gu, J., Huang, A., Haubst, N., Zehetmeier, C., Haberl, M., Elis, W., Kunz, C., Heidt, A.B., Herlihy, K., Murtie, J., Schuller, A., Arteaga, C.L., Sellers, W.R., Ettenberg, S.A. Cancer Res.