CATH Domain 4cikA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.20	Plasminogen Kringle 4
	2.40.20.10	Plasminogen Kringle 4

Domain Context

CATH Clusters

Superfamily	Plasminogen Kringle 4
Functional Family

Enzyme Information

3.4.21.7

Plasmin.

based on mapping to UniProt P00747

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.

-!- Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.14.

UniProtKB Entries (1)

P00747

PLMN_HUMAN

Homo sapiens

Plasminogen

PDB Structure

PDB	4CIK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction. Cheng, L., Pettersen, D., Ohlsson, B., Schell, P., Karle, M., Evertsson, E., Pahlen, S., Jonforsen, M., Plowright, A.T., Bostrom, J., Fex, T., Thelin, A., Hilgendorf, C., Xue, Y., Wahlund, G., Lindberg, W., Larsson, L., Gustafsson, D. Acs Med.Chem.Lett.