CATH Domain 4bk5A03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.50	Tumor Necrosis Factor Receptor, subunit A; domain 2
	2.10.50.10	Tumor Necrosis Factor Receptor, subunit A, domain 2

Domain Context

CATH Clusters

Superfamily	Tumor Necrosis Factor Receptor, subunit A, domain 2
Functional Family	Ephrin type-A receptor 5

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P54764

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54764

EPHA4_HUMAN

Homo sapiens

Ephrin type-A receptor 4

PDB Structure

PDB	4BK5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Seiradake, E., Schaupp, A., Del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A.R., Klein, R., Jones, E.Y. Nat.Struct.Mol.Biol.