CATH Domain 3kryB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt P45452

UniProtKB Entries (1)

MMP13_HUMAN

Homo sapiens

Collagenase 3

PDB Structure

PDB	3KRY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease Becker, D.P., Barta, T.E., Bedell, L.J., Boehm, T.L., Bond, B.R., Carroll, J., Carron, C.P., Decrescenzo, G.A., Easton, A.M., Freskos, J.N., Funckes-Shippy, C.L., Heron, M., Hockerman, S., Howard, C.P., Kiefer, J.R., Li, M.H., Mathis, K.J., McDonald, J.J., Mehta, P.P., Munie, G.E., Sunyer, T., Swearingen, C.A., Villamil, C.I., Welsch, D., Williams, J.M., Yu, Y., Yao, J. J.Med.Chem.