CATH Domain 2izzD01

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Pyrroline-5-carboxylate reductase 1

1.5.1.2

Pyrroline-5-carboxylate reductase.

based on mapping to UniProt P32322

L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.

-!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.

P5CR1_HUMAN

Homo sapiens

Pyrroline-5-carboxylate reductase 1, mitochondrial

PDB	2IZZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Pyrroline-5-Carboxylate Reductase Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U. To be Published