CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Glycine N-methyltransferase |
Enzyme Information
| 2.1.1.20 |
Glycine N-methyltransferase.
based on mapping to UniProt Q14749
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
|
UniProtKB Entries (1)
| Q14749 |
GNMT_HUMAN
Homo sapiens
Glycine N-methyltransferase
|
PDB Structure
| PDB | 2AZT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Destabilization of human glycine N-methyltransferase by H176N mutation.
Protein Sci.
|
