CATH Domain 1ldtT01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Anionic trypsin-2

Enzyme Information

3.4.21.4

Trypsin.

based on mapping to UniProt P00761

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (2)

P00761	TRYP_PIG Sus scrofa Trypsin
P80424	LDTI_HIRME Hirudo medicinalis Leech-derived tryptase inhibitor C

PDB Structure

PDB	1LDT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Saccharomyces
Primary Citation	The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition. Stubbs, M.T., Morenweiser, R., Sturzebecher, J., Bauer, M., Bode, W., Huber, R., Piechottka, G.P., Matschiner, G., Sommerhoff, C.P., Fritz, H., Auerswald, E.A. J.Biol.Chem.