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CATH Superfamily 2.60.40.3130

Coronavirus S1 glycoprotein, central receptor binding domain (RBD)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Coronavirus S1 glycoprotein, central receptor binding domain (RBD)

Coronaviruses enter cells through a large spike protein on their envelopes. The coronavirus spike protein is a membrane-anchored trimer and contains 2 subunits, receptor-binding subunit S1 and membrane-fusion subunit S2. The S1 subunits from group I and group II coronaviruses have no obvious sequence homology. Nevertheless, they can both be divided approximately into N-terminal region, central region, and C-terminal region. The S1 central regions of both NL63 coronavirus and SARS coronavirus are defined receptor-binding domains (RBDs) that are sufficient for high-affinity binding to their common receptor PMID:19901337. This entry represents the RBD which adopts a galectin-like fold PMID:22876187.

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
72 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 8
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 3
Taxonomy
Unique Species: 72