CATH Domain 6r8xA02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Coagulation factor XI

3.4.21.27

Coagulation factor XIa.

based on mapping to UniProt P03951

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

FA11_HUMAN

Homo sapiens

Coagulation factor XI

PDB	6R8X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans. Koch, A.W., Schiering, N., Melkko, S., Ewert, S., Salter, J., Zhang, Y., McCormack, P., Yu, J., Huang, X., Chiu, Y.H., Chen, Z., Schleeger, S., Horny, G., DiPetrillo, K., Muller, L., Hein, A., Villard, F., Scharenberg, M., Ramage, P., Hassiepen, U., Cote, S., DeGagne, J., Krantz, C., Eder, J., Stoll, B., Kulmatycki, K., Feldman, D.L., Hoffmann, P., Basson, C.T., Frost, R.J.A., Khder, Y. Blood