CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Acetylcholinesterase

Enzyme Information

3.1.1.7
Acetylcholinesterase.
based on mapping to UniProt P22303
Acetylcholine + H(2)O = choline + acetate.
-!- Acts on a variety of acetic esters. -!- Also catalyzes transacetylations.

UniProtKB Entries (1)

P22303
ACES_HUMAN
Homo sapiens
Acetylcholinesterase

PDB Structure

PDB 6O5R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.
Gerlits, O., Kong, X., Cheng, X., Wymore, T., Blumenthal, D.K., Taylor, P., Radic, Z., Kovalevsky, A.
J.Biol.Chem.