CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Collagenase 3 |
Enzyme Information
| 3.4.24.17 |
Stromelysin 1.
based on mapping to UniProt P08254
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.
|
UniProtKB Entries (1)
| P08254 |
MMP3_HUMAN
Homo sapiens
Stromelysin-1
|
PDB Structure
| PDB | 6N9D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition.
J.Biol.Chem.
|
