CATH Domain 6n2kA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	KRAS proto-oncogene, GTPase

Enzyme Information

UniProtKB Entries (1)

RASK_HUMAN

Homo sapiens

GTPase KRas

PDB Structure

PDB	6N2K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. Fell, J.B., Fischer, J.P., Baer, B.R., Ballard, J., Blake, J.F., Bouhana, K., Brandhuber, B.J., Briere, D.M., Burgess, L.E., Burkard, M.R., Chiang, H., Chicarelli, M.J., Davidson, K., Gaudino, J.J., Hallin, J., Hanson, L., Hee, K., Hicken, E.J., Hinklin, R.J., Marx, M.A., Mejia, M.J., Olson, P., Savechenkov, P., Sudhakar, N., Tang, T.P., Vigers, G.P., Zecca, H., Christensen, J.G. ACS Med Chem Lett