CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9H9B1
2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9H9B1
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9H9B1
EHMT1_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase EHMT1

PDB Structure

PDB 6MBP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
Milite, C., Feoli, A., Horton, J.R., Rescigno, D., Cipriano, A., Pisapia, V., Viviano, M., Pepe, G., Amendola, G., Novellino, E., Cosconati, S., Cheng, X., Castellano, S., Sbardella, G.
J. Med. Chem.