CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.170 | Beta Complex | |
2.170.270 | Beta-clip-like | |
2.170.270.10 | SET domain |
Domain Context
CATH Clusters
Superfamily | SET domain |
Functional Family | Euchromatic histone-lysine N-methyltransferase 2 |
Enzyme Information
2.1.1.- |
Methyltransferases.
based on mapping to UniProt Q9H9B1
|
2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9H9B1
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
Q9H9B1 |
EHMT1_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase EHMT1
|
PDB Structure
PDB | 6MBP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
J. Med. Chem.
|