CATH Domain 6jnkA01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.376	L-arabinose 1-dehydrogenase (NAD(P)(+)). based on mapping to UniProt Q53TZ2 L-arabinose + NAD(P)(+) = L-arabinono-1,4-lactone + NAD(P)H. -!- The enzymes from the bacterium Azospirillum brasilense and the archaeon Haloferax volcanii are part of the L-arabinose degradation pathway and prefer NADP(+) over NAD(+). -!- In vitro the enzyme from Azospirillum brasilense shows also high catalytic efficiency with D-galactose.
1.1.1.48	D-galactose 1-dehydrogenase. based on mapping to UniProt Q53TZ2 D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH. -!- This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
1.1.1.120	Galactose 1-dehydrogenase (NADP(+)). based on mapping to UniProt Q53TZ2 D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH. -!- Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.

UniProtKB Entries (1)

ARAA_AZOBR

Azospirillum brasilense

L-arabinose 1-dehydrogenase (NAD(P)(+))

PDB Structure

PDB	6JNK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insights into the catalytic and substrate recognition mechanisms of bacterial l-arabinose 1-dehydrogenase. Watanabe, Y., Iga, C., Watanabe, Y., Watanabe, S. Febs Lett.