CATH Domain 6iphA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.210	Beta Polymerase; domain 3
	3.30.210.10	DNA polymerase, thumb domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, thumb domain
Functional Family	DNA-directed DNA/RNA polymerase mu

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q9NP87

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9NP87

DPOLM_HUMAN

Homo sapiens

DNA-directed DNA/RNA polymerase mu

PDB Structure

PDB	6IPH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. Chang, Y.K., Huang, Y.P., Liu, X.X., Ko, T.P., Bessho, Y., Kawano, Y., Maestre-Reyna, M., Wu, W.J., Tsai, M.D. J.Am.Chem.Soc.