CATH Domain 6id1y00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.330	RRM (RNA recognition motif) domain

Domain Context

CATH Clusters

Superfamily	3.30.70.330
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q9UNP9

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q96DI7

SNR40_HUMAN

Homo sapiens

U5 small nuclear ribonucleoprotein 40 kDa protein

PDB Structure

PDB	6ID1
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structures of the human spliceosomes before and after release of the ligated exon. Zhang, X., Zhan, X., Yan, C., Zhang, W., Liu, D., Lei, J., Shi, Y. Cell Res.