CATH Domain 6i04D01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Immunoglobulin kappa chain variable 12-38

Enzyme Information

UniProtKB Entries (1)

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	6I04
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Casaletto, J.B., Geddie, M.L., Abu-Yousif, A.O., Masson, K., Fulgham, A., Boudot, A., Maiwald, T., Kearns, J.D., Kohli, N., Su, S., Razlog, M., Raue, A., Kalra, A., Hakansson, M., Logan, D.T., Welin, M., Chattopadhyay, S., Harms, B.D., Nielsen, U.B., Schoeberl, B., Lugovskoy, A.A., MacBeath, G. Proc.Natl.Acad.Sci.USA