CATH Domain 6gihA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Casein kinase II subunit alpha

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P68400

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P68400

CSK21_HUMAN

Homo sapiens

Casein kinase II subunit alpha

PDB Structure

PDB	6GIH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel non-ATP competitive small molecules targeting the CK2 alpha / beta interface. Brear, P., North, A., Iegre, J., Hadje Georgiou, K., Lubin, A., Carro, L., Green, W., Sore, H.F., Hyvonen, M., Spring, D.R. Bioorg. Med. Chem.