1 keywords

CATH Domain 6g5kB01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.200  

Domain Context

CATH Clusters

Superfamily 2.60.120.200
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P10844
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P21579
SYT1_HUMAN
Homo sapiens
Synaptotagmin-1
P10844
BXB_CLOBO
Clostridium botulinum
Botulinum neurotoxin type B

PDB Structure

PDB 6G5K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.
Elliott, M., Favre-Guilmard, C., Liu, S.M., Maignel, J., Masuyer, G., Beard, M., Boone, C., Carre, D., Kalinichev, M., Lezmi, S., Mir, I., Nicoleau, C., Palan, S., Perier, C., Raban, E., Zhang, S., Dong, M., Stenmark, P., Krupp, J.
Sci Adv