CATH Domain 6g5kA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.80	Trefoil
	2.80.10	Trefoil (Acidic Fibroblast Growth Factor, subunit A)
	2.80.10.50

Domain Context

CATH Clusters

Superfamily	2.80.10.50
Functional Family

Enzyme Information

3.4.24.69

Bontoxilysin.

based on mapping to UniProt P10844

Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.

-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P21579	SYT1_HUMAN Homo sapiens Synaptotagmin-1
P10844	BXB_CLOBO Clostridium botulinum Botulinum neurotoxin type B

PDB Structure

PDB	6G5K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Elliott, M., Favre-Guilmard, C., Liu, S.M., Maignel, J., Masuyer, G., Beard, M., Boone, C., Carre, D., Kalinichev, M., Lezmi, S., Mir, I., Nicoleau, C., Palan, S., Perier, C., Raban, E., Zhang, S., Dong, M., Stenmark, P., Krupp, J. Sci Adv