CATH Domain 6g2jF04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1440	de novo design (two linked rop proteins)
	1.20.1440.230	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain

Domain Context

CATH Clusters

Superfamily	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Functional Family	Mitochondrial NADH dehydrogenase flavoprotein 1

Enzyme Information

1.6.99.3

NADH dehydrogenase.

based on mapping to UniProt Q91YT0

NADH + acceptor = NAD(+) + reduced acceptor.

-!- After preparations have been subjected to certain treatments cytochrome c may act as acceptor. -!- Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. -!- Present in a mitochondrial complex as EC 7.1.1.2. -!- Formerly EC 1.6.2.1.

7.1.1.2

NADH:ubiquinone reductase (H(+)-translocating).

based on mapping to UniProt Q91YT0

NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).

-!- The complex is present in mitochondria and aerobic bacteria. -!- Breakdown of the complex can release EC 1.6.99.3. -!- In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH. -!- Formerly EC 1.6.5.3.

UniProtKB Entries (1)

Q91YT0

NDUV1_MOUSE

Mus musculus

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

PDB Structure

PDB	6G2J
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Agip, A.A., Blaza, J.N., Bridges, H.R., Viscomi, C., Rawson, S., Muench, S.P., Hirst, J. Nat. Struct. Mol. Biol.