CATH Domain 6g28A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.4080	ADP-ribosylglycohydrolase fold
	1.10.4080.10	ADP-ribosylation/Crystallin J1

Domain Context

CATH Clusters

Superfamily	ADP-ribosylation/Crystallin J1
Functional Family	ADP-ribosylarginine hydrolase isoform X1

Enzyme Information

3.2.2.19

[Protein ADP-ribosylarginine] hydrolase.

based on mapping to UniProt P54922

(1) Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + protein-L-arginine. (2) N(omega)-(ADP-D-ribosyl)-L-arginine + H(2)O = ADP-D-ribose + L-arginine.

-!- The enzyme will remove ADP-D-ribose from arginine residues in ADP- ribosylated proteins.

UniProtKB Entries (1)

P54922

ADPRH_HUMAN

Homo sapiens

[Protein ADP-ribosylarginine] hydrolase

PDB Structure

PDB	6G28
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Rack, J.G.M., Ariza, A., Drown, B.S., Henfrey, C., Bartlett, E., Shirai, T., Hergenrother, P.J., Ahel, I. Cell Chem Biol