CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.660 | Polyamine Oxidase; Chain A, domain 2 | |
3.90.660.10 |
Domain Context
CATH Clusters
Superfamily | 3.90.660.10 |
Functional Family | Amine oxidase [flavin-containing] B |
Enzyme Information
1.4.3.4 |
Monoamine oxidase.
based on mapping to UniProt P27338
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide. -!- Formerly EC 1.4.3.9.
|
UniProtKB Entries (1)
P27338 |
AOFB_HUMAN
Homo sapiens
Amine oxidase [flavin-containing] B
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PDB Structure
PDB | 6FW0 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis.
J. Med. Chem.
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