CATH Domain 6fs0L01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Immunoglobulin lambda variable 2-8

Enzyme Information

UniProtKB Entries (1)

MCL1_HUMAN

Homo sapiens

Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB	6FS0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Tron, A.E., Belmonte, M.A., Adam, A., Aquila, B.M., Boise, L.H., Chiarparin, E., Cidado, J., Embrey, K.J., Gangl, E., Gibbons, F.D., Gregory, G.P., Hargreaves, D., Hendricks, J.A., Johannes, J.W., Johnstone, R.W., Kazmirski, S.L., Kettle, J.G., Lamb, M.L., Matulis, S.M., Nooka, A.K., Packer, M.J., Peng, B., Rawlins, P.B., Robbins, D.W., Schuller, A.G., Su, N., Yang, W., Ye, Q., Zheng, X., Secrist, J.P., Clark, E.A., Wilson, D.M., Fawell, S.E., Hird, A.W. Nat Commun