CATH Domain 6fifA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.80	Alpha-Beta Horseshoe
	3.80.10	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
	3.80.10.10	Ribonuclease Inhibitor

Domain Context

CATH Clusters

Superfamily	Ribonuclease Inhibitor
Functional Family	Brassinosteroid LRR receptor kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O22476

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt O22476

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O22476

BRI1_ARATH

Arabidopsis thaliana

Protein BRASSINOSTEROID INSENSITIVE 1

PDB Structure

PDB	6FIF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors. Hohmann, U., Santiago, J., Nicolet, J., Olsson, V., Spiga, F.M., Hothorn, L.A., Butenko, M.A., Hothorn, M. Proc. Natl. Acad. Sci. U.S.A.