CATH Domain 6f7bA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Mitotic checkpoint serine/threonine-protein kinase BUB1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O43683

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O43683

BUB1_HUMAN

Homo sapiens

Mitotic checkpoint serine/threonine-protein kinase BUB1

PDB Structure

PDB	6F7B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo. Siemeister, G., Mengel, A., Fernandez-Montalvan, A.E., Bone, W., Schroder, J., Zitzmann-Kolbe, S., Briem, H., Prechtl, S., Holton, S.J., Monning, U., von Ahsen, O., Johanssen, S., Cleve, A., Putter, V., Hitchcock, M., von Nussbaum, F., Brands, M., Ziegelbauer, K., Mumberg, D. Clin.Cancer Res.