CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family KRAS proto-oncogene, GTPase

Enzyme Information

UniProtKB Entries (1)

Q07889
SOS1_HUMAN
Homo sapiens
Son of sevenless homolog 1

PDB Structure

PDB 6EPL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig, R.C., Sautier, B., Schroeder, J., Moosmayer, D., Hilpmann, A., Stegmann, C.M., Werbeck, N.D., Briem, H., Boemer, U., Weiske, J., Badock, V., Mastouri, J., Petersen, K., Siemeister, G., Kahmann, J.D., Wegener, D., Bohnke, N., Eis, K., Graham, K., Wortmann, L., von Nussbaum, F., Bader, B.
Proc. Natl. Acad. Sci. U.S.A.
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