CATH Domain 6dneA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	Bromodomain-containing protein 4

Enzyme Information

UniProtKB Entries (1)

BRD4_HUMAN

Homo sapiens

Bromodomain-containing protein 4

PDB Structure

PDB	6DNE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Ren, C., Zhang, G., Han, F., Fu, S., Cao, Y., Zhang, F., Zhang, Q., Meslamani, J., Xu, Y., Ji, D., Cao, L., Zhou, Q., Cheung, K.L., Sharma, R., Babault, N., Yi, Z., Zhang, W., Walsh, M.J., Zeng, L., Zhou, M.M. Proc. Natl. Acad. Sci. U.S.A.