CATH Domain 6daiA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	WD repeat-containing protein 5

Enzyme Information

UniProtKB Entries (1)

WDR5_HUMAN

Homo sapiens

WD repeat-containing protein 5

PDB Structure

PDB	6DAI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. Wang, F., Jeon, K.O., Salovich, J.M., Macdonald, J.D., Alvarado, J., Gogliotti, R.D., Phan, J., Olejniczak, E.T., Sun, Q., Wang, S., Camper, D., Yuh, J.P., Shaw, J.G., Sai, J., Rossanese, O.W., Tansey, W.P., Stauffer, S.R., Fesik, S.W. J. Med. Chem.