CATH Domain 6d59B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.840	Son of Sevenless (SoS) protein; Chain S, domain 2
	1.10.840.10	Ras guanine-nucleotide exchange factors catalytic domain

Domain Context

CATH Clusters

Superfamily	Ras guanine-nucleotide exchange factors catalytic domain
Functional Family	son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

SOS1_HUMAN

Homo sapiens

Son of sevenless homolog 1

PDB Structure

PDB	6D59
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W. J. Med. Chem.