CATH Domain 6co2B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	U8 snoRNA-decapping enzyme

Enzyme Information

3.6.1.64

Inosine diphosphate phosphatase.

based on mapping to UniProt Q96DE0

(1) IDP + H(2)O = IMP + phosphate. (2) dIDP + H(2)O = dIMP + phosphate.

-!- The human enzyme also hydrolyzes GDP and dGDP, and to a lesser extent ITP, dITP and XTP.

3.6.1.62

5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.

based on mapping to UniProt Q96DE0

5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-diphosphate + 5'-phospho-[mRNA].

-!- Decapping of mRNA is a critical step in eukaryotic mRNA turnover. -!- The enzyme is unable to cleave a free cap structure (m(7)GpppG). -!- The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+). -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96DE0

NUD16_HUMAN

Homo sapiens

U8 snoRNA-decapping enzyme

PDB Structure

PDB	6CO2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Botuyan, M.V., Cui, G., Drane, P., Oliveira, C., Detappe, A., Brault, M.E., Parnandi, N., Chaubey, S., Thompson, J.R., Bragantini, B., Zhao, D., Chapman, J.R., Chowdhury, D., Mer, G. Nat. Struct. Mol. Biol.