CATH Domain 6c57B00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Geranylgeranyl pyrophosphate synthase

Enzyme Information

2.5.1.10	(2E,6E)-farnesyl diphosphate synthase. based on mapping to UniProt O95749 Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate. -!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
2.5.1.29	Geranylgeranyl diphosphate synthase. based on mapping to UniProt O95749 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. -!- Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
2.5.1.-	Transferring alkyl or aryl groups, other than methyl groups. based on mapping to UniProt O95749
2.5.1.1	Dimethylallyltranstransferase. based on mapping to UniProt O95749 Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. -!- Will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

GGPPS_HUMAN

Homo sapiens

Geranylgeranyl pyrophosphate synthase

PDB Structure

PDB	6C57
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. Lacbay, C.M., Waller, D.D., Park, J., Gomez Palou, M., Vincent, F., Huang, X.F., Ta, V., Berghuis, A.M., Sebag, M., Tsantrizos, Y.S. J. Med. Chem.