CATH Domain 6bzhE01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.533	Death Domain, Fas
	1.10.533.10	Death Domain, Fas

Domain Context

CATH Clusters

Superfamily	Death Domain, Fas
Functional Family	Probable ATP-dependent RNA helicase DDX58

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt Q6Q899

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q6Q899

DDX58_MOUSE

Mus musculus

Probable ATP-dependent RNA helicase DDX58

PDB Structure

PDB	6BZH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of a second binding site on the TRIM25 B30.2 domain. D'Cruz, A.A., Kershaw, N.J., Hayman, T.J., Linossi, E.M., Chiang, J.J., Wang, M.K., Dagley, L.F., Kolesnik, T.B., Zhang, J.G., Masters, S.L., Griffin, M.D.W., Gack, M.U., Murphy, J.M., Nicola, N.A., Babon, J.J., Nicholson, S.E. Biochem. J.