CATH Domain 6bz9A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1460

Domain Context

CATH Clusters

Superfamily	3.40.50.1460
Functional Family	Caspase-1

Enzyme Information

3.4.22.36

Caspase-1.

based on mapping to UniProt P29466

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

-!- Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. -!- Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. -!- Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1- beta, a potent mediator of inflammation. -!- Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor. -!- Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. -!- Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans. -!- Belongs to peptidase family C14.

UniProtKB Entries (1)

P29466

CASP1_HUMAN

Homo sapiens

Caspase-1

PDB Structure

PDB	6BZ9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Yang, J., Liu, Z., Wang, C., Yang, R., Rathkey, J.K., Pinkard, O.W., Shi, W., Chen, Y., Dubyak, G.R., Abbott, D.W., Xiao, T.S. Proc. Natl. Acad. Sci. U.S.A.