CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1270 | Substrate Binding Domain Of Dnak; Chain:A; Domain 2 |
|
1.20.1270.420 |
Domain Context
CATH Clusters
| Superfamily | 1.20.1270.420 |
| Functional Family | Serine/threonine-protein kinase TBK1 |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9UHD2
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (1)
| Q9UHD2 |
TBK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase TBK1
|
PDB Structure
| PDB | 6BOE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.
Mol. Pharmacol.
|
