CATH Domain 6bnsB00

Superfamily	Retinoid X Receptor
Functional Family	Nuclear receptor subfamily 1 group I member 2

2.3.1.48

Histone acetyltransferase.

based on mapping to UniProt Q15788

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.

-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

NCOA1_HUMAN

Homo sapiens

Nuclear receptor coactivator 1

PDB	6BNS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (ROR gamma /RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity. Gong, H., Weinstein, D.S., Lu, Z., Duan, J.J., Stachura, S., Haque, L., Karmakar, A., Hemagiri, H., Raut, D.K., Gupta, A.K., Khan, J., Camac, D., Sack, J.S., Pudzianowski, A., Wu, D.R., Yarde, M., Shen, D.R., Borowski, V., Xie, J.H., Sun, H., D'Arienzo, C., Dabros, M., Galella, M.A., Wang, F., Weigelt, C.A., Zhao, Q., Foster, W., Somerville, J.E., Salter-Cid, L.M., Barrish, J.C., Carter, P.H., Dhar, T.G.M. Bioorg. Med. Chem. Lett.