CATH Domain 6b5aA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.200	Carbonic Anhydrase II
	3.10.200.10	Alpha carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Alpha carbonic anhydrase
Functional Family	Carbonic anhydrase 2

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt P00918

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918

CAH2_HUMAN

Homo sapiens

Carbonic anhydrase 2

PDB Structure

PDB	6B5A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. Nocentini, A., Bua, S., Lomelino, C.L., McKenna, R., Menicatti, M., Bartolucci, G., Tenci, B., Di Cesare Mannelli, L., Ghelardini, C., Gratteri, P., Supuran, C.T. ACS Med Chem Lett