CATH Domain 6b16A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13153

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13153

PAK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PAK 1

PDB Structure

PDB	6B16
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors. Lee, W., Crawford, J.J., Aliagas, I., Murray, L.J., Tay, S., Wang, W., Heise, C.E., Hoeflich, K.P., La, H., Mathieu, S., Mintzer, R., Ramaswamy, S., Rouge, L., Rudolph, J. Bioorg. Med. Chem. Lett.