CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family U8 snoRNA-decapping enzyme

Enzyme Information

3.6.1.64
Inosine diphosphate phosphatase.
based on mapping to UniProt Q96DE0
(1) IDP + H(2)O = IMP + phosphate. (2) dIDP + H(2)O = dIMP + phosphate.
-!- The human enzyme also hydrolyzes GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
3.6.1.62
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
based on mapping to UniProt Q96DE0
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-diphosphate + 5'-phospho-[mRNA].
-!- Decapping of mRNA is a critical step in eukaryotic mRNA turnover. -!- The enzyme is unable to cleave a free cap structure (m(7)GpppG). -!- The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+). -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96DE0
NUD16_HUMAN
Homo sapiens
U8 snoRNA-decapping enzyme

PDB Structure

PDB 6B09
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.
Thirawatananond, P., McPherson, R.L., Malhi, J., Nathan, S., Lambrecht, M.J., Brichacek, M., Hergenrother, P.J., Leung, A.K.L., Gabelli, S.B.
Sci Rep
CATH-Gene3D is a Global Biodata Core Resource Learn more...