CATH Domain 6azvD01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.58	Methane Monooxygenase Hydroxylase; Chain G, domain 1
	1.20.58.480

Domain Context

CATH Clusters

Superfamily	1.20.58.480
Functional Family

Enzyme Information

1.13.11.52

Indoleamine 2,3-dioxygenase.

based on mapping to UniProt P14902

(1) D-tryptophan + O(2) = N-formyl-D-kynurenine. (2) L-tryptophan + O(2) = N-formyl-L-kynurenine.

-!- Requires ascorbic acid and methylene blue for activity. -!- Has broader substrate specificity than EC 1.13.11.11. -!- Is induced in response to pathological conditions and host-defense mechanisms. -!- While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. -!- Superoxide radicals can replace O(2) as oxygen donor.

UniProtKB Entries (1)

P14902

I23O1_HUMAN

Homo sapiens

Indoleamine 2,3-dioxygenase 1

PDB Structure

PDB	6AZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. Nelp, M.T., Kates, P.A., Hunt, J.T., Newitt, J.A., Balog, A., Maley, D., Zhu, X., Abell, L., Allentoff, A., Borzilleri, R., Lewis, H.A., Lin, Z., Seitz, S.P., Yan, C., Groves, J.T. Proc. Natl. Acad. Sci. U.S.A.