CATH Domain 6apzA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.360	Malate synthase, domain 3

Domain Context

CATH Clusters

Superfamily	Malate synthase, domain 3
Functional Family	Malate synthase G

Enzyme Information

2.3.3.9

Malate synthase.

based on mapping to UniProt A5U3K4

Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.

-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

A5U3K4

MASZ_MYCTA

Mycobacterium tuberculosis H37Ra

Malate synthase G

PDB Structure

PDB	6APZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Anion-pi Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids. Ellenbarger, J.F., Krieger, I.V., Huang, H.L., Gomez-Coca, S., Ioerger, T.R., Sacchettini, J.C., Wheeler, S.E., Dunbar, K.R. J Chem Inf Model

Network disruptions